Cartilage Oligomeric Matrix Protein (COMP) and Hyaluronic Acid (HA): Diagnostic Biomarkers of Knee Osteoarthritis
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منابع مشابه
Cartilage Oligomeric Matrix Protein (COMP) and Hyaluronic Acid (HA): Diagnostic Biomarkers of Knee Osteoarthritis
Osteoarthritis (OA), leads to considerable morbidity and disability in elderly [1]. The condition is diagnosed basically on clinical presentation and radiographic findings. By the time changes are visible on radiographs the disease is fairly advanced. Radiographic changes are apparent only after a year or two, but changes in biomarker levels are apparent within a few months [2]. Biomarkers are ...
متن کاملCartilage Oligomeric Matrix Protein (COMP): A Biomarker of Arthritis
Arthritis is a chronic disease with a significant impact on the population. It damages the cartilage, synovium, and bone of the joints causing pain, impairment, and disability in patients. Current methods for diagnosis of and monitoring the disease are only able to detect clinical manifestations of arthritis late in the process. However, with the recent onset of successful treatments for rheuma...
متن کاملSerum levels of Cartilage Oligomeric Matrix Protein (COMP) increase temporarily after physical exercise in patients with knee osteoarthritis
BACKGROUND COMP (Cartilage oligomeric matrix protein) is a matrix protein, which is currently studied as a potential serum marker for cartilage processes in osteoarthritis (OA). The influence of physical exercise on serum COMP is not fully elucidated. The objective of the present study was to monitor serum levels of COMP during a randomised controlled trial of physical exercise vs. standardised...
متن کاملMeta-analysis of serum C-reactive protein and cartilage oligomeric matrix protein levels as biomarkers for clinical knee osteoarthritis
BACKGROUND The roles of C-reactive protein (CRP) and cartilage oligomeric matrix protein (COMP) in knee osteoarthritis (KOA) remain controversial, thus the present study is aimed to explore the relationships between CRP, COMP, and the incidence/progression of KOA. METHODS A systematic search was conducted on PubMed and Embase until September, 2016 for all the relevant studies. The pooled mean...
متن کاملClinical comparison of oral administration and viscosupplementation of hyaluronic acid (HA) in early knee osteoarthritis.
PURPOSE Osteoarthritis (OA) is a progressive, chronic and degenerative joint disease characterized by a loss of articular cartilage. Treatment of OA is largely palliative based on nonsteroidal anti-inflammatory drugs, opioids and injections of steroids. Regarding conservative treatment, intra-articular injections of hyaluronic acid (HA) can play a role in early symptomatic knee OA. MATERIALS ...
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ژورنال
عنوان ژورنال: MOJ Orthopedics & Rheumatology
سال: 2015
ISSN: 2374-6939
DOI: 10.15406/mojor.2015.02.00044